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Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis
27 January 2012
Naresh Punwani, Peggy Scherle, Robert Flores, Jack Shi, Jinjin Liang, Swamy Yeleswaram, Richard Levy, William Williams, Alice Gottlieb
Background: Janus-associated kinases (JAKs) are involved in signal transduction from a variety of cytokines implicated in the pathogenesis of psoriasis, including interleukin (IL)-12, IL-23, and inter...
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Recognition of melanoma: A dermatologic clinical competency in medical student education
27 January 2012
Jacqueline M. Goulart, Stephen Dusza, Amanda Pillsbury, Rainier P. Soriano, Allan C. Halpern, Ashfaq A. Marghoob
Background: Non-dermatologist physicians are well positioned for opportunistic melanoma detection; however, education in the skin cancer examination is limited during medical school and traditionally ...
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A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita
24 January 2012
Mark J. Eliason, Sancy A. Leachman, Bing-jian Feng, Mary E. Schwartz, C. David Hansen
Background: Pachyonychia congenita (PC) is a group of autosomal dominant keratinizing disorders caused by a mutation in one of 4 keratin genes. Previous classification schemes have relied on data from...
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Delusional infestation: Clinical presentation in 147 patients seen at Mayo Clinic
24 January 2012
Ashley A. Foster, Sara A. Hylwa, Jessica E. Bury, Mark D.P. Davis, Mark R. Pittelkow, J. Michael Bostwick
Background: Delusional infestation is the conviction that one’s skin is infested with foreign organisms or materials despite contradictory objective evidence. Objective: To delineate clinical characte...
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Recognizing large-cell transformation of mycosis fungoides
20 January 2012
Jennifer L. Herrmann, Lauren C. Hughey
Background: Although patients with mycosis fungoides (MF) typically experience an indolent disease course, a minority undergo a process of large-cell transformation (LCT), which often heralds more agg...
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