Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan

  • Tuan-Chun Hua
    Affiliations
    Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
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  • Pei-I Chung
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Yi-Ju Chen
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan
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  • Lung-Chi Wu
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan

    Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan

    Department of Dermatology, National Defense Medical Center, Taipei, Taiwan
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  • Yen-Da Chen
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Chian-Yaw Hwang
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
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  • Szu-Yin Chu
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Chih-Chiang Chen
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Ding-Dar Lee
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Yun-Ting Chang
    Correspondence
    Reprint requests: Yun-Ting Chang, MD, PhD, Department of Dermatology, Taipei Veterans General Hospital and National Yang-Ming University, No. 201, Sec. 2, Shih-Pai Rd, Taipei 112, Taiwan.
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Han-Nan Liu
    Affiliations
    Department of Dermatology, National Yang-Ming University, Taipei, Taiwan

    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan

    Department of Dermatology, National Defense Medical Center, Taipei, Taiwan
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      Background

      Rosacea is a chronic inflammatory skin disease. Inflammation plays a prominent role in atherosclerosis and its complications.

      Objective

      We sought to investigate the associations of rosacea with cardiovascular disease risk factors and cardiovascular diseases from a nationwide population-based database.

      Methods

      A total of 33,553 patients with rosacea and 67,106 age- and gender-matched control subjects were identified from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Multivariate logistic regressions were performed to compare the odds of comorbidities between the 2 groups.

      Results

      Dyslipidemia (odds ratio 1.41; 95% confidence interval 1.36-1.46), coronary artery disease (odds ratio 1.35, 95% confidence interval 1.29-1.41), and hypertension (odds ratio 1.17, 95% confidence interval 1.12-1.21) were significantly associated with rosacea. Coronary artery disease remained independently associated with rosacea after adjustment for hypertension, diabetes mellitus, and dyslipidemia. Male patients with rosacea had higher risks for all comorbidities than female patients with rosacea.

      Limitations

      The National Health Insurance Research Database does not contain information regarding rosacea subtypes or disease severity, or laboratory data.

      Conclusion

      Patients with rosacea are more likely to have dyslipidemia and hypertension. They are also at increased risk of coronary artery disease after adjustment for cardiovascular disease risk factors.

      Key words

      Abbreviations used:

      CAD ( coronary artery disease), CI ( confidence interval), CVD ( cardiovascular disease), DM ( diabetes mellitus), ICD-9-CM ( International Classification of Diseases, Ninth Revision, Clinical Modification), NHIRD ( National Health Insurance Research Database), OR ( odds ratio), PAOD ( peripheral arterial occlusive disease), PON1 ( paraoxonase-1)
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