Beta-Lipohydroxy acid (LHA) is a lipophilic derivative of salicylic acid. It exhibits
a potent keratolytic effect due to the dissociation of the corneodesmosomes in the
outmost layers of the stratum corneum. In addition, topical applications of a 2% LHA
formulation increased the thicknesses of the epidermal germinative layers, stratum
Malpighi, and filaggrin layer.