Broad-spectrum anti-fungal activity of pyrithione zinc and its effect on the causes of dandruff and associated itch 1

      Purpose: Application of new molecular and biochemical tools has greatly increased our understanding of the organisms, mechanisms, and treatments of dandruff and seborrheic dermatitis. Malassezia has long been a suspected cause, implicated by its presence on skin and lipophylic nature. However, lack of correlation between the number of Malassezia and the presence and severity of dandruff has been perplexing. We investigated the presence of M. globosa and M. restricta, the in vitro potency of monographed anti-dandruff actives against M. globosa, and in vivo reduction of Malassezia restricta and multiple fungi with quantitative PCR. We correlate reduction in Malassezia and general fungi with reduction of free fatty acids and scalp flaking and itch.
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