Clinical efficacy on epidermal wound healing of topically applied madecassoside associated with copper/zinc/manganese salts

        Madecassoside, extracted from Centella asiatica, have been widely used in dermatology, in particular as wound healing agent. In addition, copper, zinc, and manganese salts are frequently used for their antibacterial and epidermal repair properties. The aim of this study was to assess the safety and efficacy of a topically applied emulsion containing madecassoside (0.3%) associated with copper/zinc/manganese salts (0.04%, 0.04%, and 0.02%, respectively) during epidermal wound healing. We investigated for 22 days (daily topical application), in 12 healthy volunteers (mean age, 25.2 yrs), the effects of this emulsion on wound healing after roof removal of section blister on volar forearm areas. At days 1, 3, 5, 8, 12, 16, and 22, clinical evaluations (scoring by the dermatologist) were made and photographs were taken in order to access the redness of the skin. During the first days of the study (days 1, 3, 5, and 8), the fringe projection method was used to follow the wound healing process in terms of surface and volume of the wound. At the end of the study (days 12, 16, and 22), biometrologic measurements were carried out to assess the recovery of the barrier function (TEWL) and the skin color (Chromameter). Our results indicate that madecassoside associated with copper/zinc/manganese salts decreased significantly ( P < .05) the inflammatory reaction. A significantly better and faster re-epidermization ( P < .001) was obtained and after 22 days, the wounds were significantly less visible on the areas treated with the association of madecassoside and copper/zinc/manganese salts. The topically applied association of madecassoside and copper/zinc/manganese salts revealed good tolerance as well as a clinical efficacy on the process of epidermal wound healing.
        To read this article in full you will need to make a payment
        AAD Member Login
        AAD Members, full access to the journal is a member benefit. Use your society credentials to access all journal content and features
        Already a print subscriber? Claim online access
        Already an online subscriber? Sign in
        Institutional Access: Sign in to ScienceDirect