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Decrease of ultraviolet A light–induced “common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial

      To the Editor: Ultraviolet (UV) radiation causes sunburn, immunosuppression, pigmentary changes, photoaging, and skin cancer in a wavelength-dependent fashion. More than 95% of the incident UV radiation is ultraviolet A (UVA; 320-400 nm), which penetrates into the dermis. It induces DNA damage through the formation of reactive oxygen species (ROS), which are involved in oxidative base damage. ROS also induce matrix metalloproteinase (MMP) upregulation, which is partially responsible for skin photoaging.
      • Philips N.
      • Smith J.
      • Keller T.
      • Gonzalez S.
      Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes.
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      References

        • Philips N.
        • Smith J.
        • Keller T.
        • Gonzalez S.
        Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes.
        J Dermatol Sci. 2003; 32: 1-9
        • Berneburg M.
        • Grether-Beck S.
        • Kürten V.
        • Ruzicka T.
        • Briviba K.
        • Sies H.
        • et al.
        Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.
        J Biol Chem. 1999; 274: 15345-15349
        • Berneburg M.
        • Plettenberg H.
        • Medve-König K.
        • Pfahlberg A.
        • Gers-Barlag H.
        • Gefeller O.
        • et al.
        Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin.
        J Invest Dermatol. 2004; 122: 1277-1283
        • Gombau L.
        • García F.
        • Lahoz A.
        • Fabre M.
        • Roda-Navarro P.
        • Majano P.
        • et al.
        Polypodium leucotomos extract: antioxidant activity and disposition.
        Toxicol In Vitro. 2006; 20: 464-471
        • Capote R.
        • Alonso-Lebrero J.L.
        • García F.
        • Brieva A.
        • Pivel J.P.
        • González S.
        Polypodium leucotomos extract inhibits transurocanic acid photoisomerization and photodecomposition.
        J Photochem Photobiol B. 2006; 82: 173-179