Antiitching properties of patented avocado peptides

        Objectives: Itch is defined as an unpleasant sensation evoking the desire to scratch. Cross-talk between C neuron terminals and the spatially closely related dermal mast cells seems to play an important part in the pruritus pathogenesis. Indeed, mast cell mediators, such as histamine and tryptase (via proteinase-activated receptor 2 [PAR2]) are able to stimulate C neuron terminals, therefore inducing the sensation of itch. Moreover, PAR2 is also expressed by keratinocytes, where its activation initiates inflammatory response. Although the itch pathogenesis in dry skin is not fully understood, the clinical association between itch and dry skin is well established. In this study, we investigated the antiitching and moisturizing properties of a patented natural extract, avocado peptides (AP).
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