Antiaging treatment of periorbital and perioral fine lines and wrinkles with a home-use 1440-nm laser

        Previously, nonablative laser treatment of periorbital and perioral rhytids could only be performed in an office setting by trained medical professionals. The efficacy of an FDA-cleared nonablative 1440-nm laser device designed for consumer home-use treatment of periorbital and perioral rhytids was evaluated in a 22-week study under nurse treatment conditions. Fifty-eight healthy female panelists, ages 40-70 years, Fitzpatrick skin type I-IV, provided informed consent to participate in this evaluator-blinded IRB-approved study. Panelists were treated on periorbital and perioral sites by nurses, 5×/wk over the course of 12 weeks. Initially, the high setting of the device was used for all treatments. 24-hour posttreatment, the treating nurses evaluated clinical irritation (if any), and would move to the low setting or skip a treatment if warranted. After the initial 12 week period a randomly selected subset (N = 20) continued on a 2×/wk maintenance regimen for a further 4 weeks. All panelists were evaluated in-person by an independent dermatologist using the validated 0-9 Fitzpatrick Wrinkle Scale (FWS, ½ point increments allowed), and separate evaluation was performed with digital photos, 3D evaluation of texture (Primos), and panelist surveys at baseline and after 4, 8, 12, and 16 (maintenance) weeks of treatment as well as a 6 weeks follow up after the last treatment (no treatment regression). Treatments were well tolerated, with 38 panelists receiving the majority of treatments using the high setting of the device and good protocol compliance to the total number of treatments. The most common side effect was mild erythema, with an occurrence rate of only 0.57%. Independent blinded dermatologist assessment of photodamage showed significant reduction to periorbital lines and wrinkles by 2 weeks of treatment, and by week 12 for the perioral site. After 12 weeks of treatment 93.1% and 60.3% of subjects showed improvement in the periorbital and perioral sites, respectively (mean FWS reduction P < .05 of 1.22 ± 0.09, 0.34 ± 0.08). In the maintenance group, these benefits were maintained after 2×/wk treatment, and similarly efficacy was maintained in both maintenance and nonmaintenance groups in follow up evaluations 6 weeks after the last treatment. Panelist surveys confirmed the benefits to lines and wrinkles observed clinically. The results of this study showed good tolerance and efficacy for treating periorbital and perioral wrinkles with the 1440nm home-use device.
        To read this article in full you will need to make a payment
        AAD Member Login
        AAD Members, full access to the journal is a member benefit. Use your society credentials to access all journal content and features
        Already a print subscriber? Claim online access
        Already an online subscriber? Sign in
        Institutional Access: Sign in to ScienceDirect