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Incidence and survival of sebaceous carcinoma in the United States

Published:October 06, 2016DOI:https://doi.org/10.1016/j.jaad.2016.07.046

      Background

      Information on risk factors, epidemiology, and clinical characteristics of sebaceous carcinoma (SC) is limited.

      Objective

      We sought to analyze trends in SC in the United States from 2000 through 2012.

      Methods

      We used data from the 18 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from 2000 to 2012 to calculate the cause of death, relative frequencies/incidences, 5-/10-year Kaplan-Meier survival, hazard ratios, and incidence rates for SC. Each parameter was analyzed by age, location of occurrence (ocular/extraocular), race, sex, and SEER registry.

      Results

      Overall incidence was 0.32 (male) and 0.16 (female) per 100,000 person-years. Incidence significantly increased, primarily because of an increase among men. Incidence among whites was almost 3 times the rate among non-whites. Male sex (P < .0001), black race (P = .01), and extraocular anatomic location (P < .0001) were associated with significantly higher all-cause mortality. However, overall case-specific mortality for SC decreased significantly.

      Limitations

      Underregistration of patients in SEER registries, lack of verification of individual diagnoses, and low levels of staging data because of low stage-classification rate are limitations.

      Conclusions

      The overall incidence of SC is increasing significantly. Male sex, black race, and extraocular occurrences are associated with significantly greater mortality.

      Key words

      Abbreviations used:

      APC (annual percent change), CI (confidence interval), DFSP (dermatofibrosarcoma protuberans), HR (hazard ratio), SC (sebaceous carcinoma), SEER (Surveillance, Epidemiology, and End Results)
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