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Topical 15% resorcinol for hidradenitis suppurativa: An uncontrolled prospective trial with clinical and ultrasonographic follow-up

      To the Editor: Boer and Jemec first described the use of topical 15% resorcinol for hidradenitis suppurativa (HS) in a small retrospective study in 2010,
      • Boer J.
      • Jemec G.B.
      Resorcinol peels as a possible self-treatment of painful nodules in hidradenitis suppurativa.
      reporting a marked decrease in pain and mean duration of the lesions. In this study we assessed the effects of resorcinol in a prospective open trial in HS by using both clinical measures and ultrasonography. Ultrasound examination in HS provides anatomic information that is clinically unavailable and may be helpful for follow-up.
      • Wortsman X.
      • Moreno C.
      • Soto R.
      • Arellano J.
      • Pezo C.
      • Wortsman C.
      Ultrasound in-depth characterization and staging of hidradenitis suppurativa.
      • Wortsman X.
      • Jemec G.B.
      Real-time compound imaging ultrasound of hidradenitis suppurativa.
      We recruited participants with Hurley stage I and II HS. Resorcinol was the only prescribed treatment, and participants applied it twice daily for 30 days. We selected a single lesion (≤20 mm in size) per participant for study inclusion (fistulous lesions were excluded). Each participant was evaluated at baseline and after 7 days and 30 days of treatment (Fig 1).
      Figure thumbnail gr1
      Fig 1A, Inflammatory nodule at baseline. B, Clinical improvement after 7 days of treatment. C, Clinical resolution at day 30. D, Fluid collection on ultrasound at baseline. E, Partial improvement at day 7. F, Small hypoechoic area still remains at day 30.
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      References

        • Boer J.
        • Jemec G.B.
        Resorcinol peels as a possible self-treatment of painful nodules in hidradenitis suppurativa.
        Clin Exp Dermatol. 2010; 35: 36-40
        • Wortsman X.
        • Moreno C.
        • Soto R.
        • Arellano J.
        • Pezo C.
        • Wortsman C.
        Ultrasound in-depth characterization and staging of hidradenitis suppurativa.
        Dermatol Surg. 2013; 39: 1835-1842
        • Wortsman X.
        • Jemec G.B.
        Real-time compound imaging ultrasound of hidradenitis suppurativa.
        Dermatol Surg. 2007; 33: 1340-1342