Obesity and risk for incident rosacea in US women

  • Suyun Li
    Affiliations
    School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China
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  • Eunyoung Cho
    Affiliations
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island

    Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island

    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
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  • Aaron M. Drucker
    Affiliations
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island
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  • Abrar A. Qureshi
    Affiliations
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island

    Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island

    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
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  • Wen-Qing Li
    Correspondence
    Correspondence to: Wen-Qing Li, PhD, Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02912.
    Affiliations
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island

    Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island
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Published:October 21, 2017DOI:https://doi.org/10.1016/j.jaad.2017.08.032

      Background

      The relationship between obesity and rosacea is poorly understood.

      Objective

      To conduct the first cohort study to determine the association between obesity and risk for incident rosacea.

      Methods

      A total of 89,886 participants were included from the Nurses’ Health Study II (1991-2005). Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. Information on obesity was collected biennially during follow-up.

      Results

      Over 14 years of follow-up, we identified 5249 incident cases of rosacea. The risk for rosacea was elevated for those with increased body mass index (BMI, P trend < .0001). Compared with a BMI of 21.0-22.9 kg/m 2, the hazard ratio of rosacea was 1.48 (95% confidence interval 1.33-1.64) for BMI ≥ 35.0. There was a trend toward an increased risk for rosacea among participants who had gained weight after age 18 years ( P trend < .0001), with a hazard ratio of 1.04 (95% confidence interval 1.03-1.05) per 10-lb weight gain. We also observed significantly increased risk for rosacea associated with higher waist circumference and hip circumference ( P trend < .0001), and the associations appeared to be independent of BMI.

      Limitations

      This epidemiologic study did not explore underlying mechanisms of the association.

      Conclusions

      Measures of obesity were significantly associated with an increased risk for incident rosacea.

      Keywords

      Abbreviations used:

      BMI ( body mass index), CI ( confidence interval), HR ( hazard ratio), NHS II ( Nurses' Health Study II), WHR ( waist-hip ratio)
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