Basal cell carcinoma

Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations
      As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. The first article in this series describes our current understanding of this disease regarding epidemiology, cost, clinical and histopathologic presentations, carcinogenesis, natural history, and disease associations.

      Key words

      Abbreviations used:

      BCC (basal cell carcinoma), Hh (Hedgehog signaling), KC (keratinocyte carcinoma), NBCC (nevoid basal cell carcinoma syndrome), PNI (perineural invasion), SCC (squamous cell carcinoma), Shh (Sonic hedgehog protein), UV (ultraviolet)
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