Improvement of skin hydration in sensitive skin sufferers using moisturizer containing substantive carbohydrate humectant

        Individuals with sensitive skin often demonstrate a weaker stratum corneum barrier function and require effective moisturization to improve their overall skin condition. Moisturizers often contain humectants to improve skin hydration. However, due to their small molecular size, some of these humectants are only retained in skin for a few hours. It would be more optimal for moisturizers to use a combination of humectants, some of which are designed to provide more sustained moisturization. In the study conducted here, a newly marketed sensitive skin moisturizer, which contains both glycerin and a hydroscopic carbohydrate complex (CC) that binds to skin, was tested for fast-acting and long-term moisturization efficacy. Similar to NMFs, this plant derived carbohydrate complex (CC) helps provide humectancy. The CC also provides enhanced substantivity by binding to corneocyte proteins via a Maillard reaction with the corneocyte protein’s free ε-amino groups. Once bound to the skin surface, CC cannot be washed off easily like other low molecular weight humectants. Thus, removal of CC occurs only by desquamation. To evaluate the hydration benefit of the sensitive skin moisturizer containing CC, two clinical studies were conducted. The first clinical study was an IRB-approved double blind study where the sensitive skin moisturizer was applied to the legs of 44 volunteer test subjects. Hydration was assessed using Skicon, and dryness was assessed by expert visual grading at timepoints ranging from 15 minutes to 24 hours after application. The sensitive skin moisturizer provided hydration and dryness reduction benefits at the first timepoint measured and continued to provide substantial hydration and dryness reduction benefits throughout the test. In the second clinical study, a 1% aqueous solution of CC was applied for 4 weeks onto the calves of female Caucasians (40 ± 1 years of age) according to a modified Kligman regression test protocol. The cutaneous state was evaluated using the Kligman clinical scoring scale for dry skin. In the Kligman regression test, CC improved visual signs of dry skin by 24% after 4 weeks of application and retained 20% improvement after 3 days of regression. Both of these clinical studies demonstrate that CC helps sustain moisturization and in the new sensitive skin moisturizer CC helps with constant moisture regulation which is particularly relevant to patients with sensitive skin.
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