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Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias

  • Matthew Harries
    Correspondence
    Correspondence to: Matthew Harries, PhD, FRCP, The Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, M6 8HD, UK
    Affiliations
    Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, United Kingdom

    Centre for Dermatology Research, University of Manchester, Manchester, United Kingdom

    Manchester Academic Health Science Center, Manchester, United Kingdom

    National Institute for Health Research Centre Manchester Biomedical Research Centre, Manchester, United Kingdom
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  • Hisayoshi Imanishi
    Affiliations
    Division of Dermatology, Daito Central Hospital, Daito, Osaka, Japan

    Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan
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  • Ralf Paus
    Affiliations
    Centre for Dermatology Research, University of Manchester, Manchester, United Kingdom

    Manchester Academic Health Science Center, Manchester, United Kingdom

    National Institute for Health Research Centre Manchester Biomedical Research Centre, Manchester, United Kingdom

    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida
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Published:January 10, 2019DOI:https://doi.org/10.1016/j.jaad.2018.12.055
      To the Editor: We read with great interest the article by Aguh et al,
      • Aguh C.
      • Dina Y.
      • Talbot Jr., C.C.
      • Garza L.
      Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia.
      who present gene expression profiling of scalp biopsy specimens in central centrifugal cicatricial alopecia (CCCA). We commend the authors for their comprehensive appraisal of the wider fibrosis literature and its relation to CCCA pathogenesis. Yet, physicians and researchers interested in this disease may find it useful to be reminded of relevant work “closer to home” that appears to have been overlooked.
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      References

        • Aguh C.
        • Dina Y.
        • Talbot Jr., C.C.
        • Garza L.
        Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia.
        J Am Acad Dermatol. 2018; 79: 904-912.e1
        • Harries M.J.
        • Meyer K.
        • Chaudhry I.
        • et al.
        Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche.
        J Pathol. 2013; 231: 236-247
        • Imanishi H.
        • Ansell D.M.
        • Cheret J.
        • et al.
        Epithelial-to-mesenchymal stem cell transition in a human organ: lessons from lichen planopilaris.
        J Invest Dermatol. 2018; 138: 511-519
        • Sole C.
        • Gimenez-Barcons M.
        • Ferrer B.
        • Ordi-Ros J.
        • Cortes-Hernandez J.
        Microarray study reveals a transforming growth factor-beta-dependent mechanism of fibrosis in discoid lupus erythematosus.
        Br J Dermatol. 2016; 175: 302-313
        • Harries M.J.
        • Jimenez F.
        • Izeta A.
        • et al.
        Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases.
        Trends Mol Med. 2018; 24: 435-448

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