The proportion of nevus-associated invasive melanoma differs with Breslow thickness: A cross-sectional study of 1087 cutaneous melanomas

      To the Editor: Although most melanomas appear de novo, a third of cases are nevus-associated melanomas (NAMs).
      • Martin-Gorgojo A.
      • Nagore E.
      Melanoma arising in a melanocytic nevus.
      The proportion of NAMs appears to be slightly higher when the definition is based on information provided by the patient (42%-85%)
      • Garcia-Cruz A.
      • Florez A.
      • de la Torre-Fraga C.
      • Cruces Prado M.
      Observational cross-sectional study comparing Breslow thickness of melanoma arising from naevi and melanoma de novo.
      • Weatherhead S.C.
      • Haniffa M.
      • Lawrence C.M.
      Melanomas arising from naevi and de novo melanomas—does origin matter?.
      than when it is based on the histologic assessment (4%-72%).
      • Martin-Gorgojo A.
      • Nagore E.
      Melanoma arising in a melanocytic nevus.
      • Garcia-Cruz A.
      • Florez A.
      • de la Torre-Fraga C.
      • Cruces Prado M.
      Observational cross-sectional study comparing Breslow thickness of melanoma arising from naevi and melanoma de novo.
      • Weatherhead S.C.
      • Haniffa M.
      • Lawrence C.M.
      Melanomas arising from naevi and de novo melanomas—does origin matter?.
      • Tsao H.
      • Bevona C.
      • Goggins W.
      • Quinn T.
      The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate.
      One explanation for this discrepancy is the possibility of the tumor destroying the preexisting neval component, a phenomenon that is expected to be seen mostly in thick tumors and, perhaps, in nodular melanomas. The present study compared the proportion of NAMs in invasive melanomas based on tumor thickness.
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      References

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