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Cutaneous sequelae in neonatal lupus: A retrospective cohort study

Published:October 15, 2019DOI:https://doi.org/10.1016/j.jaad.2019.09.083

      Background

      Cutaneous eruptions in neonatal lupus erythematosus (NLE) are thought to be self-resolving. Limited literature suggests cutaneous changes may persist.

      Objective

      To characterize cutaneous residua in NLE and identify predictors for their development.

      Methods

      A retrospective cohort study of patients with cutaneous NLE born between January 1980 and May 2017 was performed. Primary outcome was the proportion of patients with cutaneous residua. Secondary outcomes included associations/predictors of sequelae.

      Results

      At the last follow-up, at a mean age of 4 years (range, 0.5-18.7 years), 34% of 106 patients had cutaneous sequelae, 13% had telangiectasia, 17% had dyspigmentation, and 9% had atrophic scarring. Scarring at the last follow-up was significantly associated with the presence of skin lesions at birth (P < .001).

      Limitations

      This study was limited by the retrospective design, short follow-up duration in a subset of patients, and small sample size.

      Conclusion

      Cutaneous NLE can exhibit long-term cutaneous residua. These findings underlie the importance of accurate diagnosis, long-term monitoring, and appropriate counseling.

      Key words

      Abbreviations used:

      CNLE (cutaneous neonatal lupus erythematosus), NLE (neonatal lupus erythematosus), RNP (ribonucleoprotein), SLE (systemic lupus erythematosus)
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