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Dietary table grape protects against ultraviolet photodamage in humans: 2. molecular biomarker studies

Published:January 20, 2021DOI:https://doi.org/10.1016/j.jaad.2021.01.036
      To the Editor: Major grape polyphenols include the flavanols (catechin, epicatechin, and proanthocyanidins), stilbene compounds (resveratrol), and ellagic acid. Many of these constituents have anti-inflammatory and antineoplastic effects in murine models. Resveratrol suppresses ultraviolet (UV)-induced tumorigenesis and reduces interleukin (IL)-6 and cyclooxygenase-2 expression.
      • Pezzuto J.M.
      Resveratrol: twenty years of growth, development and controversy.
      Proanthocyanidins downregulate IL-1β, tumor necrosis factor α, and prostaglandin E2 in vitro.
      • Li W.G.
      • Zhang X.Y.
      • Wu Y.J.
      • Tian X.
      Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds.
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      References

        • Pezzuto J.M.
        Resveratrol: twenty years of growth, development and controversy.
        Biomol Ther (Seoul). 2019; 27: 1-14
        • Li W.G.
        • Zhang X.Y.
        • Wu Y.J.
        • Tian X.
        Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds.
        Acta Pharmacol Sin. 2001; 22: 1117-1120
        • Bernard J.J.
        • Gallo R.L.
        • Krutmann J.
        Photoimmunology: how ultraviolet radiation affects the immune system.
        Nat Rev Immunol. 2019; 19: 688-701
        • Arbiser J.L.
        • Nowak R.
        • Michaels K.
        • et al.
        Evidence for biochemical barrier restoration: topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis.
        Sci Rep. 2017; 7: 11198
        • Arbiser J.L.
        • Bonner M.Y.
        • Ward N.
        • Elsey J.
        • Rao S.
        Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer.
        Biochim Biophys Acta Gen Subj. 2018; 1862: 2518-2527