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Elevated serum levels of C-X-C motif chemokine ligand 10 can distinguish systemic lupus erythematosus patients from cutaneous lupus erythematosus patients

Published:April 17, 2021DOI:https://doi.org/10.1016/j.jaad.2021.04.032
      To the Editor: Serological biomarkers distinguishing cutaneous lupus erythematosus (CLE) from systemic lupus erythematosus (SLE) may help track CLE patients at risk of progression to SLE. Thus, we compared the CLE and SLE sera concentrations of C-X-C motif chemokine ligand (CXCL) 9 and CXCL10, 2 chemokines previously demonstrated to be upregulated in patients with CLE and SLE,
      • Wenzel J.
      • Wörenkämper E.
      • Freutel S.
      • et al.
      Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus.
      ,
      • Baechler E.C.
      • Batliwalla F.M.
      • Karypis G.
      • et al.
      Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
      and assessed their ability to discriminate between patient groups.
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