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Association between topical corticosteroid use and fracture risk among pediatric patients with atopic dermatitis

Published:August 21, 2021DOI:https://doi.org/10.1016/j.jaad.2021.08.030
      To the Editor: Atopic dermatitis (AD) is a chronic inflammatory disorder that frequently develops during childhood, with a prevalence of 12%-37%.
      • Mortz C.G.
      • Lauritsen J.M.
      • Bindslev-Jensen C.
      • Andersen K.E.
      Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense adolescence cohort study on atopic diseases and dermatitis.
      ,
      • van Velsen S.G.
      • Knol M.J.
      • van Eijk R.L.
      • et al.
      Bone mineral density in children with moderate to severe atopic dermatitis.
      Treatment often involves topical corticosteroids; however, there is a concern, often on the part of parents, regarding their potential effects on the bone in children.
      • van Velsen S.G.
      • Knol M.J.
      • van Eijk R.L.
      • et al.
      Bone mineral density in children with moderate to severe atopic dermatitis.
      Little is known about the risk of fracture in children with AD on topical corticosteroids. The objective of this study was to use a population-based cohort to examine the association between topical corticosteroid use and subsequent fracture risk among children diagnosed with AD prior to the age of 4 years.
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