Topical tretinoin in the treatment of aging skin

  • Author Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Jonathan S. Weiss
    Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Affiliations
    Ann Arbor, MI, USA
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  • Author Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Charles N. Ellis
    Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Affiliations
    Ann Arbor, MI, USA
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  • Author Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    John T. Headington
    Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Affiliations
    Ann Arbor, MI, USA
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  • Author Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    John J. Voorhees
    Correspondence
    Reprint requests to:Dr. John J. Voorhees, Professor and Chairman, Department of Dermatology, University of Michigan Medical Center, 1910 Taubman Center, 1500 E, Medical Center Dr., Ann Arbor, MI 48109-0314.
    Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
    Affiliations
    Ann Arbor, MI, USA
    Search for articles by this author
  • Author Footnotes
    1 From the Dermatopharmacology Unit, the Department of Dermatology, and the Department of Pathology, the University of Michigan Medical Center.
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      We review the use of topical tretinoin (all- trans-retinoic acid) in the treatment of aging skin. We have found topical tretinoin capable of improving aged-appearing skin in both a double-blind, vehicle-controlled trial and our clinic patients. The most impressive improvement occurs after application of tretinoin 0.1% cream for 8 to 12 months. Side effects have been limited to a mild, transient, and clinically insignificant burning sensation in the eyes and mild irritation of tretinoin-exposed skin.
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